Salinomycin-Induced Apoptosis in Human Prostate Cancer Cells
نویسندگان
چکیده
Salinomycin is a carboxylic polyether ionophore which was isolated from the culture super‐ natant of the bacterium Streptomyces albus in 1974 [1]. Structurally, it is composed of a penta‐ cyclic molecule with a unique tricyclic spiroketal ring system and a unsaturated sixmembered ring (Fig. 1). Its lipophilic property enables salinomycin to act in cytoplasmic and mitochondrial membranes as an ionophore with a strong preference for potassium. There‐ fore, it promotes cellular and mitochondrial potassium efflux and inhibits mitochondrial ox‐ idative phosphorylation [2, 3].
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